Beilstein J. Org. Chem.2013,9, 215–222, doi:10.3762/bjoc.9.25
phenylene units. Preliminary applications of these rods in divalent systems are shown. Inhibition studies with Pseudomonas Aeruginosa lectin LecA showed that the rigid spacer proved greatly beneficial for the inhibitory potency.
Keywords: multivalent carbohydrates; LecAinhibition; phenylene ethynylene
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Graphical Abstract
Figure 1:
Schematic depiction of (a) a rigid phenylene-ethynylene polymer core with ligands attached via flex...